Maro Itoje will not be involved against the Azzurri after suffering a recurrence of a knee injury in training.Your England team to face Italy on Saturday in the #GuinnessSixNations, LIVE on @ITVSport from 16:45 GMTPreview https://t.co/uLeASojzEL pic.twitter.com/eIu2Es3UZz— England Rugby (@EnglandRugby) March 7, 2019Italy is at the bottom of the table without a point from three games, but Eddie Jones is not expecting a walk in the park as title hopeful England looks to respond to its loss in Cardiff.The England head coach said: “Italy is a bit of an unknown quantity but when [head coach] Conor [O’Shea] allows them to play rugby they play well. Te’o comes in at inside center for his first appearance of the tournament, having recovered from a side strain, so Manu Tuilagi moves to outside center and Henry Slade drops to the bench.Prop Ellis Genge is preferred to Ben Moon, while lock Joe Launchbury replaces Courtney Lawes (calf) and Brad Shields starts at blindside flanker, with Mark Wilson named among the replacements. Related News Six Nations 2019: Maro Itoje (knee) limps out of England training; Charlie Ewels called up as cover Joe Cokanasiga will make his first Six Nations start and Ben Te’o is recalled for England’s Six Nations encounter with Italy at Twickenham on Saturday.Cokanasiga gets the nod on the right wing with Jack Nowell ruled out due to a shoulder injury as Eddie Jones makes five changes to his side that was beaten by Wales. “They have played terrific games in the Six Nations. They are fitter, physically stay in the contest a lot longer and they are quite unpredictable in the way they attack.”England: Elliot Daly, Joe Cokanasiga, Manu Tuilagi, Ben Te’o, Jonny May, Owen Farrell (captain), Ben Youngs; Ellis Genge, Jamie George, Kyle Sinckler, Joe Launchbury, George Kruis, Brad Shields, Tom Curry, Billy Vunipola.Replacements: Luke Cowan-Dickie, Ben Moon, Dan Cole, Nathan Hughes, Mark Wilson, Dan Robson, George Ford, Henry Slade.